Coronary end-to-side sleeve anastomosis using adhesive in off-pump bypass grafting in the pig.
Ann Thorac Surg
; 73(5): 1451-6, 2002 May.
Article
en En
| MEDLINE
| ID: mdl-12022532
ABSTRACT
BACKGROUND:
In the exploration of facilitated coronary anastomosis strategies, we assessed a new octylcyanoacrylate adhesive in combination with a modified end-to-side sleeve anastomosis in off-pump bypass grafting in the pig.METHODS:
Sleeve-adhesive anastomoses (n = 20) were evaluated intraoperatively, at 3 days (n = 4), and at 5 weeks (n = 16) in an off-pump, low (< or = 15 mL/min; n = 10) and high flow (approximately 60 mL/min; n = 10) porcine bypass model. All anastomoses were examined by flow measurement, angiography, and histology.RESULTS:
Anastomosis construction took 8.5 minutes (6.7 to 10.2 minutes; median [15th to 85th percentile]). At 5 weeks, all anastomoses were fully patent (FitzGibbon grade A). The adhesive did not cause impaired vessel wall healing, but was surrounded by a focal acute and limited chronic (foreign body giant cells occasionally seen) inflammatory reaction at the adventitial application site.CONCLUSIONS:
Octyl-cyanoacrylate tissue adhesive combined with end-to-side internal mammary to coronary artery sleeve anastomosis construction proved to be feasible, even in low bypass graft flow conditions (< or = 15 mL/min; prothrombotic milieu) in the pig and deserves interest in exploration of facilitated anastomosis strategies in coronary artery bypass grafting.
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Bases de datos:
MEDLINE
Asunto principal:
Adhesivos Tisulares
/
Anastomosis Quirúrgica
/
Puente de Arteria Coronaria
/
Procedimientos Quirúrgicos Mínimamente Invasivos
/
Cianoacrilatos
Límite:
Animals
Idioma:
En
Revista:
Ann Thorac Surg
Año:
2002
Tipo del documento:
Article
País de afiliación:
Países Bajos