IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway.
J Immunol
; 169(7): 3637-43, 2002 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-12244155
IL-12 is a pleiotropic cytokine that plays an important role in innate and adaptive immunity. IL-12 induces T cell proliferation and IFN-gamma secretion from activated T cells. It was also reported that IL-12 prevents apoptosis of CD4(+) T cells. However, the signaling mechanism that regulates these IL-12-induced responses is poorly understood yet. In this study, we demonstrated that IL-12 activates phosphatidylinositol 3-kinase (PI3K)/Akt pathway in murine CD4(+) T cells, and that this signaling pathway is required for IL-12-induced T cell proliferation and antiapoptotic function, but not for IFN-gamma induction. Through PI3K/Akt pathway, IL-12 up-regulates the expression of cell cycle-related molecule such as cyclin D3, and antiapoptotic molecules such as Bcl-2 and cellular inhibitors of apoptosis proteins-2, followed by down-regulation of active caspase-3. These results suggest that PI3K/Akt pathway is critical for mediating IL-12-induced CD4(+) T cell responses such as T cell proliferation and survival.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
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Transducción de Señal
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Proteínas Proto-Oncogénicas
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Proteínas Serina-Treonina Quinasas
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Interleucina-12
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Fosfatidilinositol 3-Quinasas
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2002
Tipo del documento:
Article