Peptide fragments released from Phe-caseinomacropeptide in vivo in the rat.
Peptides
; 23(10): 1773-81, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12383865
ABSTRACT
The aim of this study was to investigate the pharmacokinetics of bovine Phe-caseinomacropeptide (Phe-CMP) in the rat after oral administration. This polypeptide was monophosphorylated and mainly nonglycosylated Phe-CMP-1P. During gastrointestinal digestion and absorption, Phe-CMP-1P was degraded. Intact Phe-CMP-1P and CMP-1P were rapidly released from the stomach. In contrast, partial hydrolysis by pancreatic enzymes was observed. In vitro hydrolysis by brush-border membrane vesicles also indicated that the peptide was degraded. In the blood, "CMP-immunoreactive material" appeared rapidly, reaching a maximum level of 5.5 microg/ml at 60 min.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Fenilalanina
/
Caseínas
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
2002
Tipo del documento:
Article
País de afiliación:
Francia