Synthesis of amino- and guanidino-G-clamp PNA monomers.
Org Lett
; 4(23): 4073-5, 2002 Nov 14.
Article
en En
| MEDLINE
| ID: mdl-12423089
ABSTRACT
Syntheses of the protected amino- and guanidino-G-clamp PNA monomers, 9a and 9b, respectively, have been accomplished in eight steps from 5-bromouracil. Enhanced stacking interactions and additional hydrogen bonds with guanine should increase the affinity of PNAs incorporating these cytosine analogues for their complementary strands. [reaction see text]
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Bases de datos:
MEDLINE
Asunto principal:
Ácidos Nucleicos de Péptidos
/
Aminas
/
Guanidinas
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
España