DNA damage or growth factor withdrawal does not evoke activation of MYB transcription factors in neuronal cancer cell lines.
Neurosci Lett
; 336(3): 163-6, 2003 Jan 23.
Article
en En
| MEDLINE
| ID: mdl-12505618
ABSTRACT
It has been recently observed that MYB proteins are induced in neuronal cell cultures exposed to DNA damaging agents or growth factor deprivation. While it has been proposed that MYB proteins activity is required to bring about death in neuronal cells subjected to apoptotic stimuli, here we show that MYB is not activated in differentiated pheochromocytoma-12 cells (PC12) or LAN5 cells exposed to the DNA damaging agent campothecin or in differentiated PC12 cells subjected to nerve growth factor withdrawal. We conclude that MYB activation cannot be generalised in terminally differentiated neuronal cancer cell lines.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Transactivadores
/
Proteínas Proto-Oncogénicas
/
Proteínas de Ciclo Celular
/
Proteínas Proto-Oncogénicas c-myb
/
Proteínas de Unión al ADN
/
Factores de Crecimiento Nervioso
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido