Neointima in coronary stent does not increase during over 1-year in non-restenosed lesion at 6 months follow-up: serial volumetric intravascular ultrasound study.

The long-term outcomes of coronary artery stenting have been determined by coronary angiography only with has the limitation of determining stent expansion and neointimal proliferation at long-term follow-up. Volumetric intravascular analysis has the potential to evaluate the morphology and distribution of neointima longitudinally after coronary artery stenting. We used three-dimensional intravascular ultrasound (3-D IVUS) to evaluate serial changes in stent and neointimal volumes for over 1-year in 9 patients who did not exhibit angiographic restenosis at 6-month follow-up. Volumetric analysis by a validated Netra 3-D IVUS system was performed pre- and post-intervention, at 6-month follow-up (FU1), and at over one-year follow-up (FU2). Lumen volume in the stented lesions increased significantly after intervention, and the increase persisted until FU2. There were no significant changes in stent volume between just after stent implantation and at FU2. Neointimal volume within the stents did not change from FUI to FU2 (FU1; 38.4 +/- 9.0 mm3 vs FU2; 33.8 +/- 10.3 mm3). In 33% (3/9) of all lesions, neointimal volume increased between from 6-months to over 1-year after stent implantation. Neointimal distribution after stenting seemed to be almost equal and unrelated to the plaque burden at pre-intervention. Neointimal volume within the stents did not increase and stent volume did not change over the 1st-year in patients who did not exhibit angiographic restenosis at 6-months.