2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Bioorg Med Chem Lett
; 13(5): 829-32, 2003 Mar 10.
Article
en En
| MEDLINE
| ID: mdl-12617901
ABSTRACT
Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the discovery of high affinity antagonists which are selective (vs alpha1 and M1 receptors) and active in vivo.
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Bases de datos:
MEDLINE
Asunto principal:
Piridinas
/
Receptores de N-Metil-D-Aspartato
/
Isoquinolinas
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Suiza