Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.
Nat Neurosci
; 6(5): 453-60, 2003 May.
Article
en En
| MEDLINE
| ID: mdl-12652306
ABSTRACT
Organizing centers emit signaling molecules that specify different neuronal cell types at precise positions along the anterior-posterior (A-P) and dorsal-ventral (D-V) axes of neural tube during development. Here we report that reduction in Otx proteins near the alar-basal plate boundary (ABB) of murine midbrain resulted in a dorsal shift of Shh expression, and reduction in Otx proteins at the midbrain-hindbrain boundary (MHB) resulted in an anterior expansion of the Fgf8 domain. Our data thus indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression. Furthermore, this control is effective for conferring proper cell identity in the floor-plate region of midbrain and does not require an Otx2-specific property. We propose that this mechanism may provide both A-P and D-V positional information to neuronal precursors located within the midbrain.
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Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Mesencéfalo
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Transactivadores
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Proteínas de Homeodominio
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Tipificación del Cuerpo
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Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido