Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats.
Psychopharmacology (Berl)
; 167(2): 130-6, 2003 May.
Article
en En
| MEDLINE
| ID: mdl-12655465
ABSTRACT
RATIONALE In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol. OBJECTIVES:
The present study reexamined the role of acetaldehyde in ethanol-induced conditioned taste aversion (CTA). A first experiment compared ethanol- and acetaldehyde-induced CTA. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was administered before conditioning with either ethanol or acetaldehyde to investigate the effects of acetaldehyde accumulation.METHODS:
A classic CTA protocol was used to associate the taste of a saccharin solution with either ethanol or acetaldehyde injections. In experiment 1, saccharin consumption was followed by injections of either ethanol (0, 0.5, 1.0, 1.5 or 2.0 g/kg) or acetaldehyde (0, 100, 170 or 300 mg/kg). In experiment 2, the rats were pretreated with either saline or cyanamide (25 mg/kg) before conditioning with either ethanol or acetaldehyde.RESULTS:
Both ethanol and acetaldehyde induced significant CTA. However, ethanol produced a very strong CTA relative to acetaldehyde that induced only a weak CTA even at toxic doses. Cyanamide pretreatments significantly potentiated ethanol- but not acetaldehyde-induced CTA.CONCLUSIONS:
The present results indicate that ethanol-induced CTA does not result from brain acetaldehyde effects. In contrast, it is suggested that the reinforcing effects of brain acetaldehyde might actually reduce ethanol-induced CTA. Our results also suggest that the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol-induced CTA.
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Bases de datos:
MEDLINE
Asunto principal:
Consumo de Bebidas Alcohólicas
/
Condicionamiento Psicológico
/
Etanol
/
Acetaldehído
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
2003
Tipo del documento:
Article
País de afiliación:
España