Novel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity.
Bioorg Med Chem Lett
; 13(12): 1971-5, 2003 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-12781176
ABSTRACT
A number of water soluble bis-amino-2,6-dimethoxyphenyl ester derivatives were found to exhibit improved anaesthetic activity in mice relative to propofol 1. Of the analogues disclosed, 44 was further profiled in rodents and found to be a superior agent to propofol for the induction and maintenance of anaesthesia.
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Bases de datos:
MEDLINE
Asunto principal:
Fenoles
/
Anestésicos Intravenosos
/
Ésteres
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido