Rearrangement of the MLL gene and a region proximal to the RARalpha gene in a case of acute myelocytic leukemia M5 with a t(11;17)(q23;q21).
Cancer Genet Cytogenet
; 145(1): 54-9, 2003 Aug.
Article
en En
| MEDLINE
| ID: mdl-12885463
ABSTRACT
A case of acute myelocytic leukemia (AML) M5 subtype (French-American-British classification), in a 13-year-old girl showed the abnormal karyotype 46,XX,t(11;17)(q23;q21) in all bone marrow cells analyzed. Rearrangements involving 11q23 are frequent in cases of AML M5 and often involve the MLL gene. Nevertheless, t(11;17)(q23;q21) is very rare in this type of leukemia. In acute promyelocytic leukemia, the RARalpha gene, located at 17q21, is involved in almost all cases. Fluorescence in situ hybridization studies revealed a deletion of the C-terminal part of the MLL gene and a translocation of the RARalpha gene on the derivative chromosome 11, proximal to the remaining part of the MLL gene. However, hybridization with the LSI RARA dual color break-apart rearrangement probe showed that the RARalpha gene was not rearranged in this translocation. This is the first study reporting a t(11;17)(q23;q21) with a deletion distal to MLL gene exon 6 in a case of AML M5. Furthermore, this is the second study that strongly suggests the implication of a gene proximal and close to the RARalpha locus in a case of AML M5. According to these results, the discovery of new fusion partner genes of MLL and the precise characterization of t(11;17) will be important for the understanding of neoplastic cell differentiation in AML M5.
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Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Translocación Genética
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Cromosomas Humanos Par 11
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Cromosomas Humanos Par 17
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Proto-Oncogenes
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Leucemia Monocítica Aguda
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Receptores de Ácido Retinoico
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Proteínas de Unión al ADN
Límite:
Adolescent
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Female
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Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2003
Tipo del documento:
Article
País de afiliación:
Canadá