Evidence for the colocalization of gastrin/CCK- and PYY/PP-immunoreactive substances in the small intestine of the lizard Podarcis hispanica: immunocytochemical and ultrastructural study.
Gen Comp Endocrinol
; 88(1): 40-9, 1992 Oct.
Article
en En
| MEDLINE
| ID: mdl-1426962
ABSTRACT
Peptide tyrosine tyrosine/pancreatic polypeptide (PYY/PP)- and C-terminal gastrin/cholecystokinin (G/CCK)-immunoreactive cells were investigated in the intestine of the lizard Podarcis hispanica, using immunocytochemistry with light and electron microscopy. Immunolabeling of consecutive semithin sections revealed coexistence of PYY/PP- and C-terminal G/CCK-like substances in some cells, while in others only PYY/PP or G/CCK immunoreactivity was found. Appropriate absorption controls excluded cross-reactivity between the antisera used. Ultrastructurally G/CCK+, PYY/PP+ cells were similar to G/CCK+, PYY/PP- cells but different from PYY/PP+, G/CCK- cells. Although virtually nothing is known concerning the physiological effects of these peptides in reptiles, their colocalization in the same cells in the intestine of Podarcis hispanica suggests a close relationship between them in the regulation of the digestive process.
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Bases de datos:
MEDLINE
Asunto principal:
Colecistoquinina
/
Gastrinas
/
Polipéptido Pancreático
/
Intestino Delgado
/
Lagartos
Límite:
Animals
Idioma:
En
Revista:
Gen Comp Endocrinol
Año:
1992
Tipo del documento:
Article
País de afiliación:
España