Tuberculous meningitis in patients with and without human immunodeficiency virus infection.
Am J Med
; 93(5): 520-4, 1992 Nov.
Article
en En
| MEDLINE
| ID: mdl-1442854
ABSTRACT
OBJECTIVE:
To characterize the symptoms, signs, laboratory findings, and outcome of culture-proven meningitis due to Mycobacterium tuberculosis in patients with and without human immunodeficiency virus (HIV) infection.DESIGN:
Retrospective chart review.SETTING:
Urban public general hospital in the United States. PATIENTS Fifteen patients with and 16 without HIV infection. MEASUREMENTS Demographics, symptoms, physical exam findings, serum sodium, complete blood cell count, CD4+ cell count, cerebrospinal fluid findings, imaging data, and in-hospital mortality. MAINRESULTS:
Symptoms, signs, chest radiograph appearance, cerebrospinal fluid cell counts and chemistries, and mortality were similar in both groups (p = NS). Median CD4+ cell counts were lower in HIV-infected patients (median 99/mm3, range 7 to 251, versus 384/mm3, range 171 to 724 in those without HIV infection, p = 0.007). Intracerebral mass lesions were more common in the HIV-infected group (60% versus 14% in the uninfected group, p = 0.01), although the presence of a mass did not correlate with focal neurologic deficits, altered level of consciousness, or mortality.CONCLUSION:
With the exception of an increased incidence of intracerebral mass lesions in HIV-infected individuals, HIV infection appears to have little impact on the findings and in-hospital mortality of tuberculous meningitis.
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Bases de datos:
MEDLINE
Asunto principal:
Tuberculosis Meníngea
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Infecciones por VIH
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Infecciones Oportunistas Relacionadas con el SIDA
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Med
Año:
1992
Tipo del documento:
Article