Prolonged bleeding time in patients with lupus anticoagulant.
Thromb Haemost
; 68(5): 495-9, 1992 Nov 10.
Article
en En
| MEDLINE
| ID: mdl-1455393
ABSTRACT
Platelet adhesion to collagen under flow conditions was studied in 18 patients with lupus anticoagulant, seven of which showed a prolonged bleeding time in the presence of a normal platelet count. The effect of patient plasma, IgG and purified anticardiolipin antibodies on platelet adhesion was also examined. We found a significant reduction of platelet adhesion in patients with lupus anticoagulant, which was more evident in patients with prolonged bleeding time. This platelet adhesion defect could be attributed to a plasma factor. In fact, patients' platelets regained normal adhesion when mixed with normal plasma, whereas controls' platelets showed abnormal adhesion in the presence of patient plasma. A causative role of antiphospholipid antibodies was demonstrated in experiments using purified immunoglobulins and anticardiolipin antibodies.
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Bases de datos:
MEDLINE
Asunto principal:
Tiempo de Sangría
/
Inhibidor de Coagulación del Lupus
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Thromb Haemost
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia