A critical role for OX40 in T cell-mediated immunopathology during lung viral infection.
J Exp Med
; 198(8): 1237-42, 2003 Oct 20.
Article
en En
| MEDLINE
| ID: mdl-14568982
ABSTRACT
Respiratory infections are the third leading cause of death worldwide. Illness is caused by pathogen replication and disruption of airway homeostasis by excessive expansion of cell numbers. One strategy to prevent lung immune-mediated damage involves reducing the cellular burden. To date, antiinflammatory strategies have affected both antigen-specific and naive immune repertoires. Here we report a novel form of immune intervention that specifically targets recently activated T cells alone. OX40 (CD134) is absent on naive T cells but up-regulated 1-2 d after antigen activation. OX40-immunoglobulin fusion proteins block the interaction of OX40 with its ligand on antigen-presenting cells and eliminate weight loss and cachexia without preventing virus clearance. Reduced proliferation and enhanced apoptosis of lung cells accompanied the improved clinical phenotype. Manipulation of this late costimulatory pathway has clear therapeutic potential for the treatment of dysregulated lung immune responses.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neumonía
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Infecciones del Sistema Respiratorio
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Virosis
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Linfocitos T
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Receptores del Factor de Necrosis Tumoral
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Miembro 7 de la Superfamilia de Receptores de Factores de Necrosis Tumoral
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido