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Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients.
van der Pol, W L; Jansen, M D; Kuks, J B M; de Baets, M; Leppers-van de Straat, F G J; Wokke, J H J; van de Winkel, J G J; van den Berg, L H.
Afiliación
  • van der Pol WL; Department of Neurology-C3, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. W.L.vanderPol@neuro.azu.nl
J Neuroimmunol ; 144(1-2): 143-7, 2003 Nov.
Article en En | MEDLINE | ID: mdl-14597109
Myasthenia gravis (MG) susceptibility is partially determined by allelic heterogeneity of immune-modulatory genes. IgG receptors (FcgammaR) link the humoral and cellular branches of the immune system, and regulate immune responses and inflammation. Three FcgammaR subclasses (FcgammaRIIa, FcgammaRIIIa, and FcgammaRIIIb) exhibit functional polymorphisms, which affect efficiency of FcgammaR-mediated functions. FcgammaRIIa genotypes, but not FcgammaRIIIa and FcgammaRIIIb genotypes, were differentially distributed among 107 MG patients as compared to 239 healthy controls (Pz.Lt;0.01), with a relative increase of the FcgammaRIIa-R/R131 genotype (Odds ratio 2.4, 95% confidence interval 1.4-3.9). These data suggest that the FcgammaRIIa-R/R131 genotype is a marker for susceptibility to MG.
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Bases de datos: MEDLINE Asunto principal: Antígenos CD / Receptores de IgG / Predisposición Genética a la Enfermedad / Miastenia Gravis Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Neuroimmunol Año: 2003 Tipo del documento: Article País de afiliación: Países Bajos
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Bases de datos: MEDLINE Asunto principal: Antígenos CD / Receptores de IgG / Predisposición Genética a la Enfermedad / Miastenia Gravis Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Neuroimmunol Año: 2003 Tipo del documento: Article País de afiliación: Países Bajos