Jenamidines A to C: unusual alkaloids from Streptomyces sp. with specific antiproliferative properties obtained by chemical screening.
J Antibiot (Tokyo)
; 56(9): 747-54, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-14632283
Three new naturally occurring bicyclic alkaloids, jenamidines A (1), B (2) and C (3), were discovered and isolated from the culture broth of Streptomyces sp. (strain HKI0297) via the chemical screening approach. Fermentation, isolation, structure and biological activities of these three new secondary metabolites are reported. The jenamidines have an unusual octahydro-pyrido[1,2-a]pyrimidine skeleton. Jenamidine A (1) shows antiproliferative effects against the chronic myeloid leukaemic cell line K-562. In addition, the new tricyclic sesquiterpenoid, africantriol (4) was isolated from the same strain.
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Bases de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Alcaloides
/
Antibióticos Antineoplásicos
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania