Massive hyperdiploidy and tetraploidy in acute myelocytic leukemia and myelodysplastic syndrome.
Cancer Genet Cytogenet
; 148(1): 29-34, 2004 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-14697638
ABSTRACT
Massive hyperdiploidy (>50 chromosomes) and tetraploidy (4n) are rare cytogenetic abnormalities in myelocytic malignancies, and their significance is unknown. We report on 11 patients with acute myelocytic leukemia (AML) and two patients with a myelodysplastic syndrome (MDS) with massive hyperdiploidy (10 patients) or tetraploidy (3 patients) seen at our institution over a 12-year period. Eleven patients were male and two were female. Age range was 44-84 years (median, 70 years). Only one AML patient had a previous MDS, and no patient had therapy-related disease. One or more copies of chromosomes 8 and 19 were gained in eight patients each; other frequently gained chromosomes included 13, 15, and 21. Eight patients had structural abnormalities in addition to chromosome gain; del(5q) was most common (five patients). Eleven patients received induction chemotherapy, but only four achieved complete remission. Survival ranged from 1 to 22 months, with a median of 6 months. We conclude that massive hyperdiploidy and tetraploidy are infrequent abnormalities in AML and MDS, are seen primarily in de novo disease in older male patients and are associated with a low remission rate and short survival. Massive hyperdiploidy and tetraploidy define a prognostically unfavorable cytogenetic group in de novo AML.
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Bases de datos:
MEDLINE
Asunto principal:
Poliploidía
/
Síndromes Mielodisplásicos
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Leucemia Mieloide Aguda
/
Aberraciones Cromosómicas
Límite:
Adult
/
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos