Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma.
Int J Oral Maxillofac Surg
; 32(5): 539-43, 2003 Oct.
Article
en En
| MEDLINE
| ID: mdl-14759115
ABSTRACT
Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.
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Bases de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias Orofaríngeas
/
Proteínas Oncogénicas Virales
/
Proteína p53 Supresora de Tumor
/
Ciclina D1
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Oral Maxillofac Surg
Asunto de la revista:
ODONTOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
India