Predictive value of interleukins 6, 8 and 10, and low HLA-DR expression in acute renal failure.
Clin Nephrol
; 61(2): 103-10, 2004 Feb.
Article
en En
| MEDLINE
| ID: mdl-14989629
ABSTRACT
AIMS:
HLA-DR expression and plasma levels of pro- and anti-inflammatory cytokines (IL-6, IL-8 and IL-10) and their predictive value concerning survival of critically ill systemic inflammatory response syndrome (SIRS) patients with and without acute renal failure (ARF) were evaluated.MATERIAL:
A total of 103 consecutive adult patients with SIRS from 2 university hospital intensive care units participated in the study.METHOD:
Laboratory data for all patients were prospectively collected on the day of admission and 2 days thereafter. Patients with acute renal failure (ARF) and non-ARF patients were compared by Mann-Whitney U-test. Independent predictors of mortality were tested using forward stepwise logistic multiple regression analysis. The discriminative power of different variables was tested using receiver operating characteristic (ROC) curve analysis.RESULTS:
ARF developed in 36 patients (35%). ARF patients showed significantly lower HLA-DR expression and higher plasma levels of IL-6, IL-8 and IL-10 than non-ARF patients. In ARF, moderate discriminative power in predicting survival was observed for day 2 IL-6 and IL-10 plasma levels (AUCs 0.703 and 0.749, respectively).CONCLUSIONS:
We found no clinically significant discriminative power in predicting survival of ARF patients for monocyte HLA-DR expression or cytokine plasma levels. Therefore, our results do not support the use of HLA-DR expression or cytokine plasma levels for that purpose.
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Bases de datos:
MEDLINE
Asunto principal:
Monocitos
/
Antígenos HLA-DR
/
Interleucinas
/
Lesión Renal Aguda
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Nephrol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Finlandia