[Immunologic control of HIV-1 infection. Fantasy or soon reality?]. / Immunologische Kontrolle der HIV-1-Infektion. Wunschtraum oder bald Realität?
MMW Fortschr Med
; 145 Spec No 1: 50-4, 2003 Apr 28.
Article
en De
| MEDLINE
| ID: mdl-15011590
ABSTRACT
The human immunodeficiency virus-1 (HIV-1) preferentially infects CD4+ cells, leading to their destruction. In contrast to other viral infections, the immune system is unable to keep the HIV infection under permanent control in most cases. This failure ultimatively results in immunodeficiency with occurrence of AIDS-defining diseases. In recent years, highly active antiretroviral therapy (HAART) has become available, and the number of AIDS cases and deaths have decreased dramatically. However, limitations of HAART become more apparent, demanding greater emphasis on search for alternative approaches. Stimulation and modulation of the immune response to HIV are new and promising strategies. A prerequisite, however, is the knowledge about immunologic defense mechanisms against HIV. In this article, the major factors of innate and acquired immune responses to HIV are described.
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Bases de datos:
MEDLINE
Asunto principal:
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
/
Vacunas contra el SIDA
/
Terapia Antirretroviral Altamente Activa
/
Países en Desarrollo
Límite:
Humans
Idioma:
De
Revista:
MMW Fortschr Med
Asunto de la revista:
MEDICINA
Año:
2003
Tipo del documento:
Article