Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes.

Kennedy-Smith, Joshua J; Staben, Steven T; Toste, F Dean

Kennedy-Smith, Joshua J; Staben, Steven T; Toste, F Dean.

Afiliación

Kennedy-Smith JJ; Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.

J Am Chem Soc ; 126(14): 4526-7, 2004 Apr 14.

Article en En | MEDLINE | ID: mdl-15070364

ABSTRACT

ABSTRACT

The intramolecular addition of beta-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity.

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Bases de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos

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PubMed Links

Bases de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos