Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes.
J Am Chem Soc
; 126(14): 4526-7, 2004 Apr 14.
Article
en En
| MEDLINE
| ID: mdl-15070364
ABSTRACT
The intramolecular addition of beta-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
J Am Chem Soc
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos