The importance of family history on the development of renal disease.
Curr Opin Nephrol Hypertens
; 13(3): 337-41, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15073494
ABSTRACT
PURPOSE OF REVIEW Family history of end-stage renal disease is an important risk factor for the subsequent development of nephropathy. Multiply-affected families with members demonstrating end-stage renal disease often contain individuals with disparate etiologies of renal disease. These observations have led to the search for nephropathy susceptibility genes. RECENT FINDINGS:
Genetic loci associated with susceptibility to diabetic (3q, 18q22.3-23) and non-diabetic nephropathy (chromosome 10) have been identified. A mutation in the uromodulin gene (16p11-13) has recently been linked to medullary cystic kidney disease type 2 and familial juvenile hyperuricemic nephropathy. Familial focal segmental glomerulosclerosis is linked to the 1q25-31, 11q21-22, and 19q13 loci in different families. Several research groups are evaluating family members of individuals with nephropathy in an attempt to uncover previously undiagnosed cases of renal disease.SUMMARY:
Family members of individuals with chronic kidney disease are disproportionately affected with unrecognized and asymptomatic nephropathy. Screening of these high-risk relatives for early nephropathy, and for risk factors for nephropathy, will probably lead to successful treatment for nephropathy and slow the growing worldwide epidemic of end-stage renal disease.
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Bases de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Fallo Renal Crónico
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Nephrol Hypertens
Asunto de la revista:
ANGIOLOGIA
/
NEFROLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos