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SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis.
Timms, Graham H; Boot, John R; Broadmore, Richard J; Carney, Steven L; Cooper, Jane; Findlay, Jeremy D; Gilmore, Jeremy; Mitchell, Stephen; Moore, Nick A; Pullar, Ian; Sanger, Graham J; Tomlinson, Rosemary; Tree, Beverly B; Wedley, Susan.
Afiliación
  • Timms GH; Eli Lilly and Co. Ltd, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK. timms_graham_h@lilly.com
Bioorg Med Chem Lett ; 14(10): 2469-72, 2004 May 17.
Article en En | MEDLINE | ID: mdl-15109634
ABSTRACT
Incorporation of an SRI (serotonin reuptake inhibitor) pharmacophore into a selective 5-HT(1D) agonist has led to the discovery of a molecule having both 5-HT(1D) antagonist and SRI activity. RPS methodology was used to develop the SAR and identify potential approaches to reduce unwanted adrenergic alpha 1 and dopamine D(2) cross-reactivities.
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Bases de datos: MEDLINE Asunto principal: Antagonistas de la Serotonina / Inhibidores Selectivos de la Recaptación de Serotonina / Antagonistas del Receptor de Serotonina 5-HT1 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2004 Tipo del documento: Article País de afiliación: Reino Unido
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PubMed Links

Bases de datos: MEDLINE Asunto principal: Antagonistas de la Serotonina / Inhibidores Selectivos de la Recaptación de Serotonina / Antagonistas del Receptor de Serotonina 5-HT1 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2004 Tipo del documento: Article País de afiliación: Reino Unido