Possible role for the 5-HT1A receptor in the behavioral effects of REM sleep deprivation on free-operant avoidance responding in rat.
Psychopharmacology (Berl)
; 176(2): 123-8, 2004 Nov.
Article
en En
| MEDLINE
| ID: mdl-15118805
ABSTRACT
RATIONALE REM sleep deprivation (REMSD) has been shown to increase rates of free-operant avoidance responding. Depletion of 5-hydroxytryptamine (5-HT, serotonin) levels produces similar effects on responding. OBJECTIVE:
We studied whether the pharmacological activation of the 5-HT1A receptor would produce effects on avoidance responding similar to REMSD and depleted 5-HT levels.METHODS:
Rats were trained to lever press on a free-operant avoidance task. Dose-effect functions were established for 8-OH-DPAT (a 5-HT1A receptor agonist) (0.1-1.0 mg/kg) and WAY 100635 (a 5-HT1A receptor antagonist) (0.1-1.0 mg/kg). Rats were then exposed to REMSD (48 h) or equivalent control conditions, and then administered 8-OH-DPAT (0.6 mg/kg) and/or WAY 100635 (0.025-0.1 mg/kg).RESULTS:
Injections of 8-OH-DPAT increased rates of avoidance responding in a dose-dependent manner, while WAY 100635 did not alter responding. The effect of 8-OH-DPAT was antagonized by pre-injection of WAY 100635. REMSD and injections of 8-OH-DPAT increased rates of avoidance responding and the effects of both manipulations were reversed by pre-injection of WAY 100635.CONCLUSIONS:
Activation of the 5-HT1A receptor may be a mechanism by which REMSD increases rates of free-operant avoidance responding.
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Bases de datos:
MEDLINE
Asunto principal:
Privación de Sueño
/
Sueño REM
/
Reacción de Prevención
/
Condicionamiento Operante
/
Receptor de Serotonina 5-HT1A
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos