Is high mole count a marker of more than melanoma risk? Eczema diagnosis is associated with melanocytic nevi in children.
Arch Dermatol
; 140(5): 577-80, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15148102
ABSTRACT
BACKGROUND:
The number of melanocytic nevi is the best single marker of increased melanoma risk. In a previous study, adults with severe eczema were reported to have significantly fewer nevi than adults without eczema. OBSERVATIONS In a nested case-control design within a randomized, controlled interventional trial of additional sun protection vs standard care in 269 children, a history of eczema was reported by the parents of 44 (16%) of the children. More nevi were found in children with a parental report of previous eczema diagnosis than in children without reported eczema (median, 7.5 nevi vs 5.0 nevi; P =.01). Eczema diagnosis was most significantly associated with more melanocytic nevi in children with lightly pigmented skin (8.5 nevi vs 6.0 nevi; P <.001). In multivariate logistical regression analysis, including assessment of hair color, sun protection practices, and study assignment (intervention vs standard care), eczema status remained significantly predictive of nevi number in children (P <.001).CONCLUSIONS:
In contrast to a previous study that associated severe eczema with fewer nevi in adults, in the present study children with a reported history of eczema had more nevi than children without a reported history of eczema.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Eccema
/
Nevo Pigmentado
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Arch Dermatol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos