Acceleration of visual system development by environmental enrichment.
J Neurosci
; 24(20): 4840-8, 2004 May 19.
Article
en En
| MEDLINE
| ID: mdl-15152044
ABSTRACT
Thus far, the developmental plasticity of the visual system has been studied by altering or reducing visual experience. Here, we investigated whether a complex sensory-motor stimulation, provided by rearing animals in an enriched environment, affects visual system development. We found that raising mice in this condition causes an earlier eye opening, a precocious development of visual acuity, and an accelerated decline of white matter-induced long-term potentiation. These effects are accompanied by a precocious cAMP response element-mediated gene expression and a significant increase of BDNF protein and GAD65/67 expression in enriched pups. In addition, we showed that enriched pups experienced higher levels of licking behavior provided by adult females. Thus, rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development as ascertained at behavioral, electrophysiological, and molecular level.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estimulación Luminosa
/
Vías Visuales
/
Agudeza Visual
/
Ambiente
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia