Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.
Ann N Y Acad Sci
; 1014: 220-1, 2004 Apr.
Article
en En
| MEDLINE
| ID: mdl-15153438
ABSTRACT
PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4-induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Tumor Carcinoide
/
Genes Supresores de Tumor
/
Proteínas de Unión al ARN
/
Apoptosis
Límite:
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania