OmpF channel permeability of quinolones and their comparison with beta-lactams.
FEMS Microbiol Lett
; 74(1): 105-8, 1992 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-1516804
ABSTRACT
The diffusion rates of nalidixic acid, ofloxacin and ofloxacin's two optically active isomers through OmpF channels were measured in proteoliposomes and compared with the rates of beta-lactams. The four quinolones showed high diffusion rates, exceeding that of cephaloridine and being comparable to imipenem. There was no significant difference in diffusion rate between nalidixic acid and ofloxacin, or between the two optically active isomers. The diffusion rates of enoxacin and norfloxacin were also estimated to be higher than many beta-lactams.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas de la Membrana Bacteriana Externa
/
Escherichia coli
/
Antiinfecciosos
/
Antibacterianos
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
1992
Tipo del documento:
Article
País de afiliación:
Japón