Synthesis of polyhydroxysterols (IV): synthesis of 24-methylene-cholesta-3beta,5alpha,6beta,19-tetrol, a cytotoxic natural hydroxylated sterol.
Steroids
; 69(7): 445-9, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15246774
ABSTRACT
The cytotoxic, polyhydroxylated sterol 24-methylene-cholesta-3beta,5alpha,6beta,19-tetrol (1), previously isolated from the soft corals Nephthea albida and N. tiexieral verseveldt, was synthesized using stigmasterol as the starting material by 10 steps in 9% overall yield. The spectral data and physical constants of 1 were identical with those of the natural product. This is the first report of the synthesis of 1.
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Bases de datos:
MEDLINE
Asunto principal:
Esteroles
/
Colestanoles
Límite:
Animals
Idioma:
En
Revista:
Steroids
Año:
2004
Tipo del documento:
Article
País de afiliación:
China