Chemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice.
Indian J Physiol Pharmacol
; 47(4): 459-64, 2003 Oct.
Article
en En
| MEDLINE
| ID: mdl-15266960
ABSTRACT
Boerhaavia diffusa, Linn (Fam Nyctagenaceae), is widely used for the treatment of Jaundice in various parts of India. In the present study, cancer chemopreventive property of B. diffusa was evaluated on 7,12-dimethyl benz(a)anthracene (DMBA) induced skin papillomagenesis in male Swiss albino mice (6-7 weeks old). A single topical application of 7,12-dimethyl benz(a)anthracene (50 microg/50 microl of acetone), followed 2 weeks later by repeated application of croton oil (1% in acetone three times a week) and continued till the end of the experiment exhibited 100% tumor incidence. In contrast, mice treated topically on the shaven backs with the Boerhaavia diffusa extract at either the peri-initiational phase (i.e. 7 days before and 7 days after the application of DMBA; Group II), post initiational phase (i.e. from the day of start of croton oil treatment and continued till the end of the experiment; Group III) or continuously at the peri- and post-initiational stages (i.e. 7 days prior to DMBA application and continued till the end of the experiment; Group IV), a significant reduction in the values of tumor incidence (Group II - 65%; Group III - 30%; Group IV - 25%), average number of tumors per tumor bearing mouse (Group II - 2.8; Group III - 0.75; Group IV - 0.35) and papillomas per papilloma bearing mouse (Group II - 3.1; Group III - 2.5; Group IV - 1.2) were observed.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Nyctaginaceae
/
9,10-Dimetil-1,2-benzantraceno
Límite:
Animals
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Año:
2003
Tipo del documento:
Article