2-substituted-3H-indol-3-one-1-oxides: preparation and radical trapping properties.
Free Radic Res
; 38(5): 459-71, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15293553
ABSTRACT
A series of 2-alkyl and 2-aryl substituted-3H-indol-3-one-1-oxides was prepared and evaluated for its radical trapping properties. Spin trapping and electron paramagnetic resonance experiments demonstrate the ability of these indolone-1-oxides to trap hetero- and carbon-centered radicals. The most stable spin adducts (lifetime of several hours) are obtained with 2-alkyl substituted nitrones, the 2-ethyl-5,6-dioxolo-3H-indolone-1-oxide, 5e and the 2-secbutyl-3H-indolone-1-oxide, 5f. These two nitrones are also sensitive to redox reactions in solution. Therefore this indolone-1-oxide series lacking a beta-hydrogen atom gives rise to highly stable adducts with free radicals.
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Bases de datos:
MEDLINE
Asunto principal:
Marcadores de Spin
/
Radical Hidroxilo
/
Espectroscopía de Resonancia por Spin del Electrón
/
Superóxidos
/
Indoles
/
Óxidos de Nitrógeno
Idioma:
En
Revista:
Free Radic Res
Asunto de la revista:
BIOQUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia