Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women.
Clin Genet
; 66(4): 299-310, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15355432
ABSTRACT
Perilipin coats intracellular lipid droplets and modulates adipocyte lipolysis. We have evaluated the association between several polymorphisms at the perilipin (PLIN) locus (PLIN1 6209T > C, PLIN4 11482G > A, PLIN5 13041A > G, and PLIN6 14995A > T) with obesity-related phenotypes in 1589 White subjects randomly selected from a general Spanish population. In women (n = 801), the less common alleles of PLIN1 and PLIN4, in strong linkage disequilibrium (D' 0.96), were significantly associated with lower body mass index. Carriers of the allele 2 (6209C) at the PLIN1 locus weighed significantly less (-2.2 kg; p = 0.007) than women homozygotes for the wild-type genotype. The same was true for 11482A carriers at PLIN4 (p = 0.01). Moreover, the PLIN4 variant was associated with significantly lower waist-to-hip ratio, plasma glucose, and triacylglycerol concentrations. No significant associations with these obesity-related phenotypes were found in men. In agreement with these results, statistically significant gene-gender interactions were obtained when the risk of obesity was estimated (281 subjects were obese and 1308 non-obese). Only in women, PLIN1 and PLIN4 variant alleles (6209C and 11482A) were associated with a lower obesity risk [Odds ratio (OR) = 0.58, 95% confidence interval (CI) 0.38-0.93 and OR = 0.56, 95% CI 0.36-0.89, respectively]. In summary, our data suggest that common alleles at the PLIN locus modulate body weight and metabolic variables in humans.
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Bases de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Variación Genética
/
Obesidad
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Genet
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos