Gender differences and the effects of ketamine in healthy volunteers.
J Psychopharmacol
; 18(3): 337-9, 2004 Sep.
Article
en En
| MEDLINE
| ID: mdl-15358976
ABSTRACT
We present a critical perspective of the impact of gender differences on a widely accepted model of ketamine psychosis in healthy volunteers. Male and female patients with schizophrenia present with different symptomatology, disease course and response to pharmacological intervention. Accordingly, it is expected that ketamine psychosis in healthy volunteers fulfils this face validity. Pre-clinical studies in rats indicate a gender difference in response to ketamine administration. However, a review of the literature to date indicates that studies carried out in healthy volunteers have used all male or mixed samples, indicating the need for further studies comparing the psychopathological effects of ketamine in males and females.
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Bases de datos:
MEDLINE
Asunto principal:
Psicosis Inducidas por Sustancias
/
Ketamina
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Psychopharmacol
Asunto de la revista:
PSICOFARMACOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Reino Unido