[Blood transfusion and pretransfusion testing in patients with warm autoimmune haemolytic anaemia]. / Blodtransfusjon og pretransfusjonsutgreiing ved autoimmun hemolytisk anemi av varmetype.
Tidsskr Nor Laegeforen
; 124(22): 2918-20, 2004 Nov 18.
Article
en Nor
| MEDLINE
| ID: mdl-15550967
ABSTRACT
BACKGROUND:
In warm autoimmune haemolytic anaemia, patients have red cell autoantibodies that complicate the serological compatibility testing before transfusion. Different autoadsorption techniques are utilised for more extensive pretransfusion testing. We reviewed the literature on blood transfusion in these patients. We also present our experience with autoadsorption by papain and polyethylene glycol methods. MATERIAL ANDMETHODS:
Blood samples from 13 patients with warm autoantibodies were analysed in parallel. After autoadsorption, antibody screening and identification tests were performed to detect possible red cell alloantibodies. If the serological testing is inadequate, clinically important alloantibodies can be ignored before transfusion, which can lead to haemolytic transfusion reactions.RESULTS:
Autoantibodies were completely adsorbed in six of the 13 patients. In five, alloantibodies were detected. In three patients, different results were obtained with the two different techniques.INTERPRETATION:
Restrictive transfusion practice in warm autoimmune haemolytic anaemia is recommended. Adequate pretransfusion testing in a specialised laboratory is required before transfusion. Autoadsorption with polyethylene glycol and papain can supplement each other in pretransfusion testing.
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Bases de datos:
MEDLINE
Asunto principal:
Transfusión Sanguínea
/
Anemia Hemolítica Autoinmune
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Nor
Revista:
Tidsskr Nor Laegeforen
Año:
2004
Tipo del documento:
Article