[Revaluation of chloroquine therapeutic efficacy on children with uncomplicated Plasmodium falciparum malaria in eastern Ivory Coast (1999-2002)]. / Efficacité thérapeutique de la chloroquine dans le traitement du paludisme simple à Plasmodium falciparum de l'enfant dans l'est de la Côte-d'Ivoire (1999-2002).
Med Mal Infect
; 34(3): 127-31, 2004 Mar.
Article
en Fr
| MEDLINE
| ID: mdl-15617353
ABSTRACT
OBJECTIVE:
A prospective study was made from November 1999 to May 2002 in order to revaluate the therapeutic efficacy of chloroquine in pediatric Plamodium falciparum malaria in Ivory Coast.DESIGN:
This study was included in the national Plasmodium falciparum-susceptibility supervision program. Two hundred and fifty-six out of 594 patients from six to 59 months of age were included. Chloroquine was administered in accordance with the standard 14 day WHO protocol; i.e. administered dose of 25 mg/kg, in split doses, over three days.RESULTS:
Two hundred and forty-seven patients completed the treatment. Among these, 217 presented with adequate clinical response (87.8%). The percentage of therapeutic failure was 12.2% with 12 early cases of therapeutic failure and 18 late cases of therapeutic failure. Chloroquine was more efficacious in Agnibilékrou (11.3% of therapeutic failure), Bondoukou (10.4%), and Tanda (10%), than in Abengourou (16.4%). Parasitic reduction on patients with resistant Plasmodium was superior to 90%, from day 0 to day 3. The risk of therapeutic failure was significantly linked to patient age.CONCLUSION:
Considering these results, the authors suggest that the first-line treatment with chloroquine must be continued for uncomplicated malaria in humans.
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Bases de datos:
MEDLINE
Asunto principal:
Cloroquina
/
Malaria Falciparum
/
Antimaláricos
Tipo de estudio:
Guideline
/
Observational_studies
/
Risk_factors_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Africa
Idioma:
Fr
Revista:
Med Mal Infect
Año:
2004
Tipo del documento:
Article