Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
Genomics Proteomics Bioinformatics
; 1(4): 247-62, 2003 Nov.
Article
en En
| MEDLINE
| ID: mdl-15629054
ABSTRACT
The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Síndrome Respiratorio Agudo Grave
/
Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Genomics Proteomics Bioinformatics
Asunto de la revista:
BIOQUIMICA
/
GENETICA
/
INFORMATICA MEDICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
China