A T lymphocyte-specific transcription complex containing RUNX1 activates MHC class I expression.
J Immunol
; 174(4): 2106-15, 2005 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-15699141
ABSTRACT
MHC class I expression is subject to both tissue-specific and hormonal regulatory mechanisms. Consequently, levels of expression vary widely among tissues, with the highest levels of class I occurring in the lymphoid compartment, in T cells and B cells. Although the high class I expression in B cells is known to involve the B cell enhanceosome, the molecular basis for high constitutive class I expression in T cells has not been explored. T cell-specific genes, such as TCR genes, are regulated by a T cell enhanceosome consisting of RUNX1, CBFbeta, LEF1, and Aly. In this report, we demonstrate that MHC class I gene expression is enhanced by the T cell enhanceosome and results from a direct interaction of the RUNX1-containing complex with the class I gene in vivo. T cell enhanceosome activation of class I transcription is synergistic with CIITA-mediated activation and targets response elements distinct from those targeted by CIITA. These findings provide a molecular basis for the high levels of MHC class I in T cells.
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Bases de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Antígenos de Histocompatibilidad Clase I
/
Regulación de la Expresión Génica
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Subgrupos de Linfocitos T
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Proteínas Proto-Oncogénicas
/
Elementos de Facilitación Genéticos
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Epítopos de Linfocito T
/
Proteínas de Unión al ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos