Docking: successes and challenges.
Curr Pharm Des
; 11(3): 323-33, 2005.
Article
en En
| MEDLINE
| ID: mdl-15723628
ABSTRACT
The state of the art of various computational aspects of docking-based virtual screening of database of small molecules is presented. The review encompasses the different search algorithms and the scoring functions used in docking methods and their applications to protein and nucleic acid drug targets. Recent progress made in the development and application of methods to include target flexibility are summarized. The fundamental issues and challenges involved in comparing various docking methods are discussed. Limitations of current technologies as well as future prospects are presented.
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Bases de datos:
MEDLINE
Asunto principal:
Tecnología Farmacéutica
/
Proteínas de la Membrana
Idioma:
En
Revista:
Curr Pharm Des
Asunto de la revista:
FARMACIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos