Synergistic inhibitory effect of high-intensity focused ultrasound combined with chemotherapy on Dunning adenocarcinoma.
BJU Int
; 95(6): 881-5, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15794802
ABSTRACT
OBJECTIVE:
To evaluate the therapeutic effect of high-intensity focused ultrasound (HIFU) combined with chemotherapy (paclitaxel + estramustine) on AT2 Dunning adenocarcinoma, as no satisfactory treatment for localized prostate cancer is available for patients with a poor prognosis, e.g. stage T3, a high Gleason score, or a prostate-specific antigen level of >15 ng/mL. MATERIALS ANDMETHODS:
Forty-one Dunning AT2 tumour-bearing Copenhagen rats were divided into four groups, i.e. control, chemotherapy, HIFU, and chemotherapy + HIFU (the last three treated for 1 week). The growth in tumour volume was recorded for 3 weeks, the point at which tumour volume was considered to have doubled (doubling time). The growth curves of each group were plotted and evaluated statistically.RESULTS:
At 30 days of follow-up the distributions of tumour volume with treatment group were significantly different (P < 0.001); volumes were significantly greater in the control than in the chemotherapy-only or in the HIFU-only group (both P = 0.006). The greatest difference was between the chemotherapy + HIFU and the control group. The tumour doubling times were 13.2 days for HIFU-only, 31.2 days for chemotherapy + HIFU and 7.7 days for the controls.CONCLUSION:
These results suggest that this combined therapy could be useful for treating patients with high-risk prostate cancer.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Adenocarcinoma
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Ultrasonido Enfocado Transrectal de Alta Intensidad
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
BJU Int
Asunto de la revista:
UROLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia