Structural brain changes in bipolar disorder using deformation field morphometry.
Neuroreport
; 16(6): 541-4, 2005 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-15812303
ABSTRACT
The objective of this study was to investigate anatomical brain abnormalities in adult bipolar patients using a deformation field morphometry technique. Our sample consisted of 32 right-handed bipolar I patients (men/women=16/16) and 32 right-handed, age and gender matched healthy controls. Deformation field morphometry analysis was performed on three-dimensional spoiled gradient recalled acquisition images. We found gender-specific structural differences between bipolar patients and healthy individuals. Bipolar men had significantly larger lateral ventricles (especially pronounced in the left hemisphere) and smaller left dorsolateral prefrontal cortex than healthy male controls. Our results are complementary to the findings of functional imaging and post-mortem studies that demonstrate abnormalities in the dorsolateral prefrontal cortex in bipolar patients.
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Bases de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Imagen por Resonancia Magnética
/
Caracteres Sexuales
/
Corteza Prefrontal
/
Ventrículos Laterales
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos