Growth hormone increases hsc70/hsp70 expression and protects against apoptosis in whole blood preparations from silver sea bream.
Ann N Y Acad Sci
; 1040: 288-92, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15891044
ABSTRACT
Preparations of whole blood, from silver sea bream (Sparus sarba), were used for heat shock protein 70 (hsp70) and apoptosis studies. It was found that the expression of both gene members of the hsp70 family (hsc70 and hsp70) were upregulated during acute heat shock. The transcript abundance of both of these genes was increased when cells were exposed to growth hormone (GH) at concentrations of 10 and 100 ng/mL. It was also found that GH at concentrations of 10 and 100 ng/mL could protect whole blood from camptothecin-induced apoptosis as determined by DNA fragmentation analysis.
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Bases de datos:
MEDLINE
Asunto principal:
Hormona del Crecimiento
/
Regulación de la Expresión Génica
/
Apoptosis
/
Dorada
/
Proteínas del Choque Térmico HSC70
Límite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2005
Tipo del documento:
Article
País de afiliación:
China