Multicentric osteosarcoma presenting as retrobulbar mass: a diagnostic enigma.
Pediatr Blood Cancer
; 46(7): 815-9, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-15926165
ABSTRACT
Osteosarcoma is the most common primary malignant bone tumor of children and adolescents. It often presents as a solitary lesion; multicentric osteosarcoma with synchronous lesions occurring at multiple skeletal sites is very rare. We report a 9-year-old boy with multicentric osteosarcoma who presented with a left retrobulbar non-sclerotic mass. The multiple lesions in bone were mostly non-sclerotic on radiological examination except for a single lesion in the left tibia. Biopsy of the retrobulbar mass showed an unclassifiable poorly differentiated malignant tumor. Marrow aspiration smears showed many large, often segregated, round cells that expressed NB84a. However, trephine biopsy showed the formation of tumoral osteoid by the malignant cells, finally permitting the definitive diagnosis of osteosarcoma to be made. A hypertetraploid clone with complex structural abnormalities was demonstrated by cytogenetic study.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Óseas
/
Osteosarcoma
/
Neoplasias del Ojo
/
Neoplasias Primarias Múltiples
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Blood Cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Hong Kong