Association between neopterin and carotid intima-media thickness in hemodialysis patients.
Nephron Clin Pract
; 101(3): c134-8, 2005.
Article
en En
| MEDLINE
| ID: mdl-16015003
ABSTRACT
BACKGROUND:
Atherosclerotic lesions are heavily infiltrated by macrophages. Neopterin can be used as a marker of the activity of macrophages. Serum neopterin levels were elevated in non-renal patients with atherosclerosis. The intima-media thickness (IMT) of the carotid arteries in hemodialysis patients was significantly higher than in control subjects. In this study, we measured serum neopterin levels in hemodialysis patients and evaluated a possible correlation between neopterin levels and carotid IMT. PATIENTS ANDMETHODS:
Thirty-seven hemodialysis patients (26 male/11 female, mean age 47 +/- 15 years) and 12 healthy subjects (8 male/4 female, mean age 43 +/- 10 years) were included in this study. Serum neopterin levels were measured by using a commercial ELISA kit. Carotid IMT of the subjects were measured by high-resolution B-mode ultrasonography.RESULTS:
Carotid IMT values were 1.04 +/- 0.29 and 0.77 +/- 0.25 mm in hemodialysis patients and healthy controls, respectively (p < 0.01). Serum neopterin levels were 110.9 +/- 19.1 and 3.8 +/- 2.3 ng/ml in hemodialysis patients and healthy controls, respectively (p < 0.01). Serum neopterin levels were 103.2 +/- 21.3 ng/ml in hemodialysis patients with IMT < 1 mm (n = 15), and 116.7 +/- 15.4 ng/ml in hemodialysis patients with IMT > or = 1 mm (n = 22) (p < 0.05). Moreover, there was a significant correlation between serum neopterin levels and carotid IMT (p < 0.05, r = 0.363).CONCLUSION:
Our findings suggest that neopterin could be associated with the severity of carotid atherosclerosis in hemodialysis patients.
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Bases de datos:
MEDLINE
Asunto principal:
Arterias Carótidas
/
Diálisis Renal
/
Túnica Íntima
/
Neopterin
/
Aterosclerosis
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nephron Clin Pract
Asunto de la revista:
NEFROLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Turquía