Tight junction: a co-ordinator of cell signalling and membrane trafficking.
Biol Cell
; 97(8): 659-65, 2005 Aug.
Article
en En
| MEDLINE
| ID: mdl-16033326
ABSTRACT
Increasing evidence indicates that the tight junction plays a role in membrane transport. Various signalling and trafficking molecules localize to the sites of cell-cell junctions in epithelial cells, including Rab proteins, a family of small GTPases that regulate different steps of vesicular transport along the endocytic and exocytic pathways. We have recently shown that Rab13 controls protein kinase A activity, demonstrating a clear biochemical and functional link between Rab13 and protein kinase A signalling during tight junction assembly in epithelial cells. The present article focuses on how protein kinase A signalling and protein trafficking events could be integrated at tight junctions in epithelial cells.
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Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Membrana Celular
/
Uniones Estrechas
/
Transporte de Proteínas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Biol Cell
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia