Proteomics of plasma membrane microdomains.
Expert Rev Proteomics
; 2(5): 793-807, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-16209657
ABSTRACT
Plasma membrane microdomains represent subcompartments of the plasma membrane characterized by a specific lipid and protein composition. The recognition of microdomains in nearly all the eukaryotic membranes has accredited them with specialized functions in health and disease. Several proteomic studies have recently addressed the specific composition of plasma membrane microdomains, and will be reviewed in this paper. Peculiar information has been obtained, but a comprehensive view of the main protein classes required to define the microdomain proteome is still missing. The achievement of this information is slowed by the difficulties encountered in resolving and analyzing hydrophobic proteins, but it could help in understanding the overall function of plasma membrane microdomains and their involvement in human pathology.
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Bases de datos:
MEDLINE
Asunto principal:
Membrana Celular
/
Microdominios de Membrana
/
Proteómica
Límite:
Humans
Idioma:
En
Revista:
Expert Rev Proteomics
Asunto de la revista:
BIOQUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Italia