Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 485-9, 2005.
Article
en En
| MEDLINE
| ID: mdl-16247976
ABSTRACT
The phosphoramidate technology we have developed has been recently applied to BVdU, leading to NB1011 (NewBiotics Inc., California), a novel potential anticancer compound recently entered into phase 2 of the clinical trials for colon cancer. We report in this work a new series of derivatives containing naphthol as aryl masking group on the phosphate moiety, which has shown a significant increase in anticancer activity in preliminary biological evaluations.
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Bases de datos:
MEDLINE
Asunto principal:
Ácidos Fosfóricos
/
Bromodesoxiuridina
/
Amidas
/
Antineoplásicos
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido