TGF-beta as a T cell regulator in colitis and colon cancer.
Cytokine Growth Factor Rev
; 17(1-2): 97-106, 2006.
Article
en En
| MEDLINE
| ID: mdl-16298544
ABSTRACT
TGF-beta is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-beta1 show a dramatic phenotype with severe multiorgan inflammation and die shortly after birth. Recent investigations have highlighted the role of TGF-beta in suppression of T cell mediated autoimmune inflammation and anti-tumor immunity. In addition to its direct anti-inflammatory effects on T cells, TGF-beta has been implicated as central regulator of regulatory T cells. TGF-beta not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-beta along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25- cells.
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Bases de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos T
/
Factor de Crecimiento Transformador beta
/
Colitis
/
Neoplasias del Colon
/
Mediadores de Inflamación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Alemania