Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
Bioorg Med Chem Lett
; 16(5): 1397-401, 2006 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-16337120
ABSTRACT
The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.
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Bases de datos:
MEDLINE
Asunto principal:
Piridinas
/
Diseño de Fármacos
/
Proteína Quinasa 10 Activada por Mitógenos
/
Compuestos de Anilina
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Suecia