Regulating the regulator: negative regulation of Cbl ubiquitin ligases.
Trends Biochem Sci
; 31(2): 79-88, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16406635
ABSTRACT
Cbl proteins are regulators of signal transduction through many pathways and, consequently, regulate cell function and development. They are ubiquitin ligases that ubiquitinate and target many signaling molecules for degradation. The Cbl proteins themselves are regulated by an increasingly complex network of interactions that fine-tune the effects that Cbl proteins have on signaling. The negative regulation of Cbl protein function can occur via cis-acting structural elements that prevent inappropriate ubiquitin ligase activity, degradation of the Cbl proteins, inhibition without degradation owing to interaction with other signaling proteins, deubiquitination of Cbl substrates, and regulation of assembly of the endosomal ESCRT-I complex. Defects in the regulatory mechanisms that control Cbl function are implicated in the development of immunological and malignant diseases.
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Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Regulación Enzimológica de la Expresión Génica
/
Proteínas Proto-Oncogénicas c-cbl
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos